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History and physical exam donor advocate physician ; Psychosocial evaluation social work, psychiatry ; Laboratory assessment CBC, chemistry, coagulation profile Thrombophilia screening, viral serologies HIV, HBV, HCV, etc. ; ECG, chest radiograph Cardiac stress testing, if indicated Liver imaging MRI, MRA, MRV, MRCP, or CT scan ERCP ; Liver biopsy, if indicated Family agreement consent, no evidence of compensation coercion.
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13 feb 21, 2007 been on diovan for about two years ems to work but b p still fluctuates dramatically.
DIOVAN HCT has not been studied in children under 18 years of age. What should I tell my doctor before taking DIOVAN HCT? Tell your doctor about all your medical conditions including if you: are pregnant or planning to become pregnant. See "What is the most important information I should know about DIOVAN HCT?" are breast-feeding. DIOVAN HCT passes into breast milk. You should choose either to take DIOVAN HCT or breast-feed, but not both. have a heart condition.
Carol used to drink diet drinks all the time and she relies on diet products. She couldn't understand why she always craved sweets when she saw them and she binged on them at social occasions. Possibly it was because the artificially sweetened foods still allowed her to like the sweet taste. However, by gradually adding water to her beverages, Carol learned to acquire a taste for less sweet foods. She still likes chocolate cake but now a few bites will satisfy her. She actually finds the cake too sweet. The goal is to change your taste rather than simply reduce the calorie intake which does not address the real problem. If you have a sweet tooth you can gradually learn to like less sweet foods.
| Diovan prescription drugControlled trial of the experimental neuroleptic drug flupenthixol, researchers noted a significant reduction in suicide-attempt behavior in adults who had made numerous previous attempts Montgomery & Montgomery, 1982 ; . Similar studies have yet to be conducted on adolescents, although trials of SSRIs in depressed adolescents suggest that these drugs are effective for treating depression and for reducing suicidal ideas also in this age group Emslie et al., 1997; Ryan & Varma, 1998 ; . Because placebocontrolled, methodologically appropriate studies of tricyclic antidepressants have failed to find a significant effect in depressed children and adolescents Ryan & Varma, 1998 ; , it is reasonable to regard SSRIs as a first-choice medication in treating depressed suicidal children and adolescents also see American Academy of Child and Adolescent Psychiatry, 1998 ; . In contrast to tricyclic antidepressants, SSRIs have low lethal potential when taken in overdoses Ryan & Varma, 1998 ; . In adults with major depressive disorder, controlled research suggests that lithium reduces suicide risk Thies-Flechtner et al., 1996 ; , but this has not yet been demonstrated in children and adolescents. Clinicians should be cautious about prescribing medications that may reduce self-control, such as the benzodiazapines, amphetamines, and phenobarbital. These drugs also have a high lethal potential if taken in overdose Carlsten et al., 1996 and hytrin.
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| USE IN PREGNANCY: When used in pregnancy, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, valsartan or DIOVAN HCT should be discontinued as soon as possible. Valsartan and DIOVAN HCT are contraindicated in patients who are hypersensitive to any component of these products. Because of the thiazide component, DIOVAN HCT is contraindicated in patients with anuria or hypersensitivity to sulfonamidederived drugs. Volume- and or salt-depletion should be corrected in patients prior to administering valsartan or DIOVAN HCT or symptomatic hypotension may occur. Care should be exercised with dosing of valsartan in patients with severe renal impairment. As a consequence of inhibiting the renin-angiotensin system, changes in renal function may be observed in susceptible individuals eg, patients with renal artery stenosis or severe heart failure ; . Important considerations due to the hydrochlorothiazide component: Thiazide diuretics should be used with caution in patients with impaired hepatic function or progressive liver disease. Lithium generally should not be given with thiazides. Thiazides have been reported to cause exacerbation or activation of systemic lupus erythematosus. Patients taking DIOVAN HCT should be observed for clinical signs of fluid or electrolyte imbalance. Valsartan and DIOVAN HCT are indicated for the treatment of hypertension. DIOVAN HCT is for patients who need even more than valsartan or HCTZ alone and is not indicated for initial therapy. Please see brief summary of full Prescribing Information on adjacent pages.
With the black box warning for pregnancy, it should not be used for pregnant women and discontinued in women who are thinking about getting pregnant. It also has a contraindication in volume-depleted patients and volume depletion should be corrected prior to initiating therapy. Cozaar is one of the most widely used angiotensin II receptor blockers. It has been on the Medicaid formulary for two years. It is indicated for hypertension, but it also has unique indications for stroke prevention and kidney protection in type II diabetics. Derek Terada: An associate director with Boehringer Ingelheim, Mr. Terada discussed Telmisartan Micardis ; . In clinical trials, as well as community practice trials, Micardis' efficacy has shown to be sustained over the full 24-hour dosing period. The INNOVATION trial evaluated whether two doses of Telmisartan, 40- or 80-milligrams once daily, could delay the progression of insipient nephropathy to overt nephropathy versus placebo. The trial included 527 hypertensive and normal-tensive Japanese patients treated for a year with all three drugs. The primary endpoint was how many patients converted from insipient to overt nephropathy. The results indicated that half of the patients in the placebo group transitioned over to overt nephropathy in a year. Telmisartan, 40-milligrams, cut the risk by 55% and only 22.6% of those patients transitioned. Telmisartan, 80-milligrams, cut the risk by 66% and only 16.7% of those patients transitioned. The secondary endpoint was how many patients regressed to normal albuminuria when they started off with microalbuminuria. Both doses of Telmisartan were effective, but the higher dose was much more effective in regression rates. On Telmisartan, 40milligrams, 12% of the patients regressed whereas on Telmisartan, 80-milligrams, 21% of the patients regressed. The study concluded that at least two doses of Telmisartan could effectively delay the progression from insipient to overt nephropathy. At this point, Telmisartan is only indicated for hypertension. Telmisartan is on 95% of the PDLs nationally. Dr. Sater gave the First Health presentation on Angiotensin II Receptor Blockers. There are seven available products. All products are FDA indicated for hypertension, although there are a wide variety of other indications and most of the drugs in this class are used for most indications. They have similar pharmacokinetic profiles and clinical efficacy. All drugs in this class are available in combination with hydrochlorothiazide. No drug in this class is available generically. In January, there were 702 claims: 28% for Diovan, 18% for Cozaar, 16% for Diovxn with hydrochlorothiazide, 8% for Benicar, 8% for Micardis, 7% for Hyzaar, and 5% for Benicar with hydrochlorothiazide. The rest of the drugs had less than 3% of the market share. Currently Diovan, Doovan with hydrochlorothiazide, Cozaar, Hyzaar, Benicar, Benicar HCT, Micardis, and Micardis HCT are preferred. Previously, the committee discussed clinical issues with Benicar and Cozaar and the importance of having more than one agent from this class on the PDL. The motion to declare a class effect carried with four opposed. The Alaska Heart Institute provider poll yielded the same recommendations as last year. Primarily they use Diovann due to the bulk of clinical trial data, but they also use Benicar and Tevitan. Mr. Campana noted that letters had been received from several providers supporting Benicar, Avapro, and the ACE combinations. The committee discussed the definition of class effect. Dr. Maciejewski noted that some ARB medications tried to obtain indications for certain things, but did not meet the criteria. Some of the drugs have unique, but difficult to explain, adverse reactions or intolerances. We probably cannot say this is a class effect, but there should be limited choices. The committee discussed which indications they should consider. Dr. Hunt said it would be easy to declare a class effect if they were only talking about hypertension. Dr. Maciejewski felt they needed to consider the other indications. Dr. Carlson felt and atacand.
Where Nt is the number of Hg or cells at the end of the incubation period and N0 is the number of Hgr or Hgs cells at the beginning of the incubation period. Values of n are an approximation as the calculation does not take cell death during the incubation period into account. The average relative fitness of Hgr populations, wHg r , on whole membrane filters was therefore.
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This work was supported by Merck & Co through an unrestricted research grant to Brigham and Women's Hospital. The authors had sole responsibility for study design, data interpretation, and publication of findings. Dr Solomon was also supported by grants from the Arthritis Foundation and the National Institutes of Health AR48616 and AR-48264 ; . We want to thank an epidemiologist who participated actively in the study design, statistical analysis and interpretation of the data, and preparation of the manuscript. We are also grateful to Rhonda Bohn, ScD, who performed an independent review of the study protocol and statistical programming and lotensin.
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Diovan interaction with alcohol
DESOCORT CREAM, OINTMENT AND LOTION DESQUAM-X 10% DESQUAM-X WASH 10% DESYREL DESYREL DIVIDOSE DEXAMETHASONE SODIUM PHOSPHATE OPHTHALMIC SOLUTION AND INJECTION DEXASONE DEXIRON 50 mg ml INJECTION DEXTROSTIX DIABETA DIABINESE DIAMICRON 80 mg TABLETS DIAMICRON MR 30 mg SUSTAINED RELEASE TABLETS DIASCAN STRIPS DIASTIX DICETEL 50 mg, 100 mg TABLETS DICLECTIN 10 mg TABLETS DICYCLOMINE HCL SABEX ; DIDROCAL TABLETS DIHYDROERGOTAMINE MESYLATE 1 mg ml INJECTION DIHYDROERGOTAMINE SANDOZ DILANTIN TABLETS, CAPSULES AND SUSPENSION DILAUDID STERILE POWDER FOR INJECTION DILAUDID TABLETS, ORAL LIQUID, AMPULS AND SUPPOSITORIES DILAUDID-HP AND HP PLUS DILAUDID XP DIMELOR DIMETHYL SULFOXIDE 500 mg G INJECTION DIODOQUIN DIOPENTOLATE DIOPTIMYD DIOVAN 40, 80 AND 160 mg TABLETS DIOVAN-HCT 80 12.5 AND 160 12.5 mg TABLETS DIOVAN HCT 160 mg 25 mg TABLETS DIPENTUM TABLETS AND CAPSULES DIPROGEN 0.5 1 mg CREAM DIPROLENE CREAM, OINTMENT AND LOTION DIPROSALIC LOTION AND OINTMENT DIPROSONE CREAM, OINTMENT AND LOTION DIXARIT DOM-ATENOLOL 50 AND 100 mg TABLETS DOM-BACLOFEN 10 AND 20 mg TABLETS DOM-BROMOCRIPTINE 2.5 mg TABLETS DOM-BROMOCRIPTINE 5 mg CAPSULES DOM-BUSPIRONE 10 mg TABLETS DOM-CAPTOPRIL 12.5, 25, 50 AND 100 mg TABLETS DOM-CLONAZEPAM-R 0.5 mg TABLETS and lozol.
Norvasc and diovan combined
38 after curative surgical resection, patients were randomized to receive no further treatment, postoperative adjuvant chemotherapy, or postoperative radiotherapy.
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Acetylsalicylic acid 3g day ; and non-selective NSAIDs ; , attenuation of the antihypertensive effect may occur. As with ACE inhibitors, concomitant use of Angiotensin II antagonists and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function. The combination should be administered with caution, especially in the elderly. Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and periodically thereafter. Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin converting enzyme ACE ; inhibitors. Very rare cases have also been reported with angiotensin II receptor antagonists. Coadministration of lithium and valsartan should be undertaken with caution. If this combination proves essential, serum lithium level monitoring is recommended during concomitant use. 4.6 PREGNANCY AND LACTATION Due to the mechanism of action of angiotensin II antagonists, a risk factor for the fetus cannot be excluded. In utero exposure to ACE inhibitors a specific class of drugs acting on the RAAS ; during the second and third trimesters has been reported to cause injury and death to the developing fetus. There have been reports of spontaneous abortion, oligohydramnios and newborn renal dysfunction, when pregnant women have inadvertently taken valsartan. As for any drug that also acts directly on the RAAS, Diovan should not be used during pregnancy see section 4.3 "Contraindications" ; or in women planning to become preganant. Healthcare professionals prescribing Diovan should counsel women of child-bearing potential about the potential risk of this product during pregnancy. If pregnancy is detected during therapy, Diovan should be discontinued as soon as possible. It is not known whether valsartan is excreted in human milk. Valsartan was excreted in the milk of lactating rats. Thus, it is not advisable to use Diovan in lactating mothers. 4.7 EFFECTS ON ABILITY TO DRIVE AND USE MACHINES There are no data to suggest that Diovan affects the ability to drive or use machines. When driving vehicles or operating machines, it should be recognised that occasionally dizziness or weariness may occur during treatment with any antihypertensive agent. UNDESIRABLE EFFECTS In clinical trials in hypertensive patients, adverse experiences have been mild and transient in nature. The incidence of AEs showed no association with gender, age or race. The following table of AEs is based on 10 placebo-controlled clinical trials in patients with hypertension N 2316 ; and on post-marketing reports. All AEs with an incidence of 1% or more in the Diovan treatment group in placebo-controlled clinical studies are included in Table 1. The table also includes non-fatal serious adverse events SAEs ; with suspected study drug relationship reported with an incidence of 0.1% in a clinical study in patients with postmyocardial infarction N 14, 703 ; . Frequencies are defined as: very common 1 10 common 1 100, 1 uncommon 1 1000, 1 rare 1 10 000, 1 1000 very rare 1 10 000 ; . Viral infections Upper respiratory tract infection, pharyngitis, sinusitis Very rare: Rhinitis Blood and lymphatic system disorders Common Neutropenia Very rare: Thrombocytopenia Infections and infestations Common: Uncommon.
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Loss of Exclusivity for Certain Products The products of our Pharmaceuticals Division are generally protected by patents that give us the exclusive right to market them in various countries. These exclusive marketing rights are, however, limited both in terms of geographical scope and impacted by the expiration of patents. For example, patents for the antifungal medicine Lamisil will expire in June 2007 in the US, where this product accounted for 4 million in annual sales, or 1.6% of the net sales from continuing operations in 2006 3.9% of the sales from continuing operations in US ; . Similarly, patent protection for Trileptal's active ingredient has expired in the US and other major countries. In 2006, this product accounted for 9 million in sales in the US, or 1.5% of the net sales from continuing operations 3.8% of the sales from continuing operations in US ; . the ordinary course of its business, we like other major research-based pharmaceutical companies ; defend our intellectual property against challenges by generic drug manufacturers. Patent infringement actions have been initiated for a number of our Pharmaceutical Division's products, including Neoral, Lotrel, Trileptal, Femara, Visudyne, Exelon and Famvir. Loss of exclusivity and the introduction of a generic version of the same medicine typically results in a significant and sharp reduction in net sales for the relevant product, given that generic manufacturers typically offer their versions of the same medicine at sharply lower prices. Some products that are still among our top-20 selling products have already encountered generic competition in some markets, such as Lamisil, Neoral, Sandostatin SC and Voltaren. In addition, some of our products do, or may in the future, face intense competition in the form of new branded products with potentially better safety efficacy profiles or from generic versions of competing branded drugs indicated for treating the same diseases or indications. Although we have been rated by industry experts as having one of the lowest rates of net sales at risk to potential generic competition, a number of leading products could potentially face generic competition in the coming five to ten years in various markets, particularly the US and Europe. These include our top-selling products: the anti-hypertension drugs Diovan and Lotrel as well as the oncology drugs Gleevec Glivec and Zometa. Importance of Research & Development and the ability to obtain approvals for New Products Our ability to continue to grow our business and to replace any lost sales due to the loss of exclusivity for our products in the future depends upon the ability of our R&D activities to identify and develop high-potential breakthrough products and to bring them to market. Given that the development and regulatory approval for a new pharmaceutical product frequently takes more than 10 years and can involve costs of over billion, the need for efficient and productive R&D activities is critical to our continued business success. Competition in the development of new pharmaceuticals is intense since other pharmaceutical companies are also searching for efficacious and cost-efficient medicines. The sharply rising resource requirements to access the full range of new technologies, particularly following the decoding of the human genome, has been one reason for industry consolidation as well as for the increase in collaborations between major pharmaceuticals companies and specialized niche players at the forefront of their particular field. The quality of our current Pharmaceuticals Division development pipeline reflects investments made in our own R&D activities, in many cases more than ten years ago, as well as recent acquisitions and licensing collaborations. We have consistently had one of the highest R&D investment rates in the industry as a percentage of net sales, reflecting our commitment to bring innovative and differentiated products to the market with novel therapeutic benefits. Up to one-third of annual Pharmaceuticals Division R&D expenditures are used to reach licensing agreements with other companies, particularly specialized biotechnology companies, to co-develop promising pharmaceutical compounds. These co-development and alliance agreements are intended to allow us to capitalize on the potential of these compounds and to expand our development pipeline. We have entered into more than 100 alliances during 2005 and 2006 to complement internal R&D activities.
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NDA 20-665 S-016 NDA 21-283 S-001 Page 30 Blood Urea Nitrogen BUN ; : In heart failure trials, greater than 50% increases in BUN were observed in 16.6% of Diovan treated patients compared to 6.3% of placebo treated patients. OVERDOSAGE Limited data are available related to overdosage in humans. The most likely manifestations of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic vagal ; stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted. Valsartan is not removed from the plasma by hemodialysis. Valsartan was without grossly observable adverse effects at single oral doses up to 2000 mg kg in rats and up to 1000 mg kg in marmosets, except for salivation and diarrhea in the rat and vomiting in the marmoset at the highest dose 60 and 37 times, respectively, the maximum recommended human dose on a mg m2 basis ; . Calculations assume an oral dose of 320 mg day and a 60-kg patient. ; DOSAGE AND ADMINISTRATION Hypertension The recommended starting dose of Diovan valsartan ; is 80 mg or 160 mg once daily when used as monotherapy in patients who are not volume-depleted. Patients requiring greater reductions may be started at the higher dose. Diovan may be used over a dose range of 80 mg to 320 mg daily, administered once-a-day. The antihypertensive effect is substantially present within 2 weeks and maximal reduction is generally attained after 4 weeks. If additional antihypertensive effect is required over the starting dose range, the dose may be increased to a maximum of 320 mg or a diuretic may be added. Addition of a diuretic has a greater effect than dose increases beyond 80 mg. No initial dosage adjustment is required for elderly patients, for patients with mild or moderate renal impairment, or for patients with mild or moderate liver insufficiency. Care should be exercised with dosing of Diovan in patients with hepatic or severe renal impairment. Diovan may be administered with other antihypertensive agents. Diovan may be administered with or without food. Heart Failure The recommended starting dose of Diovan is 40 mg twice daily. Uptitration to 80 mg and 160 mg twice daily should be done to the highest dose, as tolerated by the patient. Consideration should be given to reducing the dose of concomitant diuretics. The maximum daily dose administered in clinical trials is 320 mg in divided doses. Concomitant use with an ACE inhibitor and a beta blocker is not recommended. HOW SUPPLIED Diovan valsartan ; is available as tablets containing valsartan 40 mg, 80 mg, 160 mg or 320 mg. All strengths are packaged in bottles and unit dose blister packages 10 strips of 10 tablets ; as described below. 40-mg tablets are round and slightly convex with bevelled edges. 80-, 160-, and 320-mg tablets are almond-shaped with bevelled edges. All tablets are unscored and accupril.
KETOROLAC TROMETHAM 30mg ml MARCAINE 0.50% ENALAPRILAT 1.25 ml PHYSIOSOL IRRIGATION IRRIGAT DEXTROSE 5% 0.90% DEXTROSE 5% NACL 0.9% DOBUTAMINE HCL D5W 1mg ml LYRICA 25mg LYRICA 50mg LYRICA 75mg LYRICA 100mg LYRICA 150mg LYRICA 200mg LYRICA 225mg LYRICA 300mg NAMENDA 10mg 5ml NIZORAL 2% TWINJECT 0.3mg TWINJECT 0.15mg LOTENSIN 20mg LOTENSIN 40mg STERILE WATER FOR INJECTI KLONOPIN 0.5mg KLONOPIN 1mg KLONOPIN 2mg VALIUM 2mg VALIUM 5mg VALIUM 10mg LOTENSIN 5mg LOTENSIN 10mg DEXAMETHASONE SODIU10mg ml DOPAMINE HCL 40mg ml LIDOCAINE HCL 2% NEVANAC 0.10% SOLAGE 0.01-2% CYTOMEL 5MCG ENCORA VECURONIUM BROMIDE 10mg DIOVAN 40mg DIOVAN 40mg KERALYT 6% Z-DEX ZYPREXA 20mg AXID 15mg ml HYPERRHO S D 300MCG HYPERRHO S D 50MCG HYPERTET S D 250 ml BAYGAM GAMASTAN S D BAYHEP B HYPERHEP B S D HYPERHEP B S D GAMUNEX 10% GAMUNEX 10% GAMUNEX 10% GAMUNEX 10% GAMUNEX 10% PROLASTIN 500mg PROLASTIN 1000mg 500UNIT THROMBATE III W 10 ml S 1000UNIT THROMBATE III W 20 ml S PLASMANATE 5% HYPERRAB S D 150 ml HYPERRAB S D 150 ml KOATE-DVI 250UNIT KOATE-DVI 500UNIT.
Fortunately for the families raising children with costello syndrome, researchers didnt have to develop a test, because the test for the mutation in cancer tumors can be used for children suspected as having costello syndrome as well.
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A major issue for people with cancer is the possibility that one drug may interact with another in a way that might alter the effectiveness of both. This is an issue called drug-drug interaction. Many people with cancer take medications for other chronic illnesses, such as heart disease and diabetes. When a cancer drug is taken along with another drug, one drug might decrease the effectiveness of the other, for example, by interfering with the body's ability to absorb it. Or, one drug may increase the effects of the other. Drug-drug interactions can be complex, so it is important to tell your doctor what medications you already take and in what dose so that your cancer treatment can be planned accordingly. Over-the-counter products, including vitamins and herbs, may also profoundly affect the way a cancer drug works. Be sure to tell your doctor about them so any potential problems can be flagged and addressed.
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Special offer: $ 91 per pill diovan diovan valsartan ; is used to treat high blood pressure and heart failure.
Brands Diovan Gleevec Glivec Lamisil group ; Zometa Lotrel Neoral Sandimmun Sandostatin group ; Lescol Voltaren group ; Trileptal Top ten products total Femara Visudyne Exelon Zelnorm Zelmac Tegretol incl. CR XR ; Miacalcic Foradil Comtan Stalevo Group Famvir Elidel Top 20 products total Rest of portfolio Total Division net sales.
No significant differences between overall incidence of adverse events AEs ; with Diovan HCT vs placebo AEs more frequent with Diovan HCT than placebo: dizziness 9% vs 7% viral infection 3% vs 1% fatigue 5% vs 1% pharyngitis 3% vs 1% coughing 3% vs 0% and diarrhea 3% vs 0% ; The most common AEs are headache and dizziness A dose-related increase in the incidence of dizziness was observed in Diovan HCTtreated patients from 80 12.5 mg 6% ; to 160 25 mg 16.
O o o For the treatment of mild to moderate essential hypertension. DIOVAN may be administered alone, or concomitantly with thiazide diuretics. The safety and efficacy of concurrent treatment with DIOVAN and angiotensin converting enzyme inhibitors have not been established.
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Drug trend was moderate for two therapeutic classes that were large contributors to drug spending in 2003: antihypertensives 3.1% ; and antiulcer medications 3.3% ; . Antihypertensives The slow spending growth for antihypertensives is the net result of two factors: increased utilization 5.5% ; and lower unit costs -2.3% ; . The utilization growth was primarily driven by a large increase in the use of angiotensin II receptor blockers ARBs ; . The unit-cost reductions were primarily due to the introduction of first-time generics for angiotensin-converting enzyme ACE ; inhibitors. Changes in utilization and cost varied significantly for different classes of antihypertensives: ARBs. These medications showed strong utilization growth 21.5% ; in 2003. Clinical use of ARBs has increased significantly in response to recent clinical guidelines that recommend these medications to treat patients who have both hypertension and diabetes.3, 4 The drug trend for ARBs has also been stimulated by their broadened use for other conditions. For example, Diovan was approved in August 2002 to treat patients who have heart failure but cannot tolerate ACE inhibitors. ACE inhibitors. Utilization of ACE inhibitors grew slightly in 2003 2.2% ; , but unit costs dropped sharply -13.5% ; . The unit-cost reductions reflect a shift in therapy mix to the first-time generics for Prinivil and Zestril lisinopril ; -- introduced in July 2002--and the introduction of generic fosinopril Monopril ; in November 2003.
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