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If you've woken up with a headache some time over the last couple of weeks then you're probably in good company. The season to be jolly sometimes becomes too jolly; and our bodies pay the price. That hung-over feeling in the morning is usually as a result of dehydration and an imbalance in our sugar metabolism. At this time of year it's usually caused by the alcoholic content of our Christmas or New Year spirits. The more we drink the worse it gets. Despite being liquid themselves, alcoholcontaining drinks wine, beer and so on ; actually take water away from the parts of our body which need it most. Drinks containing caffeine such as coffee, tea or cola can do the same. To help prevent morningafter headaches, alternate your alcoholic drinks with plenty of water. It can be helpful also to drink a long glass of sugar-sweetened cordial before bed. It may not seem like the ideal beverage at the time, but it could prevent that really awful feeling the next day. If that pain you feel needs a pain reliever, the products with paracetamol are probably the best bet; they're less likely than aspirin to cause stomach upset. Try a couple of Panadol Clear and pray the noise of the fizz is not too loud for you! Indigestion or dyspepsia are also often part of the problem caused by too much of a good thing. After a rich meal our stomachs have to work harder and pump out extra acid to help digest the food and alcohol. The pain or discomfort that follows this exercise in overindulgence can also occur with stress, cigarette smoking, pregnancy and some medicines. Apart from that uneasy, queasy feeling, often symptoms of indigestion include belching or burping and heartburn known medically as reflux ; . Belching occurs in an effort to relieve the pressure of a build-up of gas which can result from eating too much too quickly. Simple remedies containing charcoal and simethicone can help disperse the gas bubbles which cause the discomfort. Your pharmacist can help you choose an appropriate product. If heartburn is the main problem, you might get relief with a liquid antacid like Gaviscon; and a range of potent antacids in tablet form is also now available without prescription. Zahtac is one example of such products. For more advice and information tailor-made to your need to cope with the after effects of the festive season, or morning after problems at anytime, ask at your pharmacy for one of the Self Care fact cards titled Headache and Heartburn and Indigestion. They're available from pharmacies around Australia which provide the Pharmaceutical Society's Self Care health information. You can call 1 300 369 for the nearest location.

Dave blondebomb member 6302 posts posted - aug 15 2005 : : 41 hey michael, well it sounds like you have your hands full with medical problems, i can relate.

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These drugs include h2 blockers such as cimetidine tagamet ; and proton pump inhibitors such as omeprazole prilosec, losec ; - biloxi sun herald, off-label drug use oct 14, 2005 that drug as well as cimetidine tagamet ; , ranitidine zantac ; , famotidine pepcid ; , and sucralfate cara-fate ; were and in the case of all but gastro-gard.
PART II Item 13. Item 14. Item 15. Item 16A Item 16B Item 16C Item 16D Item 16E Defaults, Dividend Arrearages and Delinquencies . Material Modifications to the Rights of Security Holders and Use of Proceeds Controls and Procedures . Audit Committee Financial Expert . Code of Ethics . Principal Accountant Fees and Services . Exemptions from the Listing Standards for Audit Committees . Purchases of Equity Securities by the Issuer and Affiliated Purchasers and metoclopramide.

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Experiments using membrane capacitance as a measure of exocytosis * show that each rise of [Ca2 + ]i also initiates a burst of exocytosis of secretory granules from the gonadotrope Tse et al. 1993 ; . Hence the releasing hormone-induced oscillatory rise of [Ca2 + ]i is the physiological signal for hormone secretion in this endocrine cell. Including millimolar concentrations of EGTA or BAPTA as a cytoplasmic Ca2 + buffer in the whole-cell pipette prevents the rise of [Ca2 + ]i, the opening of K Ca ; channels, and the exocytosis. The GnRH-induced [Ca2 + ]i oscillations in gonadotropes satisfy the following criteria for Ca2 + release by intracellular IP3 receptor channels Tse and Hille 1992; Hille et al. 1995 ; : Unlike Ca2 + signals generated by voltage-gated Ca channels on the cell surface, those mediated by IP3 receptors depend little on the plasma membrane potential of the cell and do not require Ca2 + in the bath. They occur whether the cell is hyperpolarized to 120 mV or depolarized to 0 mV. GnRH does stimulate IP3 production, and including IP3 in the whole-cell pipette mimics GnRH action. Oscillations are reversibly blocked when the whole-cell pipette contains heparin or pentosan polysulfate, polyanions that compete with IP3 binding to the IP3 receptor. Oscillations also stop if reuptake of Ca2 + into the endoplasmic reticulum by SERCA pumps is inhibited by agents such as thapsigargin. The time courses of agonist-stimulated [Ca2 + ]i elevations depend on the type of cell studied and the agonist concentration. Typically the Ca2 + elevation begins after a delay of more than a few hundred milliseconds. It may rise quickly in an initial transient followed by a delayed and sustained elevation, or it may evolve into oscillations Berridge and Irvine 1989; Fewtrell 1993; Thomas et al. 1996 ; . Oscillations in different cell types have a variety of underlying mechanisms!

A week later my blood pressure was up to 160 8 then yesterday it was 170 80, and they gave me a prescription for medication and allopurinol.
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Master tag, work permit or other device; this finding is bolstered by the fact that the requirements of both 1910.147 and 1910.269, including the sign-on sign-off requirement, were the result of extensive comments, hearings and other input by interested parties, and by the fact that Appendix B to the compliance directive for 1910.269 was issued after a lengthy period of negotiations among OSHA, industry and union representatives. As to consistency, I have already found, as set out supra, that the evidence of record demonstrates that OSHA's interpretation of the standard has been consistent. This conclusion is apparent from a review of the preambles to the standards, the appendices to the compliance directives for the standards, and the interpretational letter of October 14, 1999, issued by OSHA's Directorate of Compliance Programs. With respect to the validity of OSHA's reasoning, the Secretary notes in her brief that the core principle of lockout is that each employee who is potentially exposed to hazardous energy will have his own lockout or tagout device attached to the energy isolating device during the servicing operation and that the equipment cannot be re-energized until each employee removes his own lock or tag. C-48 at 4320, 4359 ; . The Secretary also notes that the purpose of this requirement is to reduce the possibility that another individual might re-energize equipment under the mistaken impression that all authorized employees had finished their maintenance work and were removed from danger; in this regard, the preamble to 1910.269 states that "[i]t cannot be overemphasized that employees performing tasks on de-energized equipment may be exposed to hazards involving serious injury or death if the status of the lockout or tagout control can be changed without their knowledge." C-48 at 4359-60 ; . The Secretary points out that by requiring each authorized employee to place and remove his own lock or tag, the standard assures the employee will have effective, individual control over energy sources that could otherwise cause serious injury. C-48 at 4360-61 ; . The Secretary further points out that this requirement applies whether one employee or a group of employees is performing servicing work. See 1910.269 d ; 6 ; iv ; , and d ; 8 ; ii ; set out above, the Secretary contends that Exelon's tracking list is not the equivalent of a personal lockout or tagout device because each individual crew member does not sign onto and off of the tracking list; rather, the lead worker 1 ; informs the crew members of the OOS and puts a check by each employee's name on the list, 2 ; informs the crew members of the lifting of the OOS and ranitidine.
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Novartis AG is a pharmaceutical company with operations in three business segments: Healthcare, Agribusiness, and Consumer Health. Integrated pharmaceutical and healthcare company formed from the merger of Pfizer and Warner-Lambert. Brands include Halls, Tetra, Benadryl, Sudafed, Listerine, Desitin, Schick, Visine, Ben Gay, Lubriderm, Zajtac 75 and Cortizone. Four main operating divisions are: Pfizer Pharmaceuticals Group, Warner-Lambert Consumer Division, Pfizer Animal Health Group, and Pfizer Global Research and Development. Biotech that develops human and humanized antibodies and other potential drugs to prevent or treat certain disease conditions, including viral infections, autoimmune diseases and cancers. PDLI licensed its first humanized antibody product Zenapax daclizumab ; to Roche, which markets it for the prevention of kidney transplant rejection. Biopharmaceutical company focused on the development and marketing of photodynamic therapeutics. Currently, QLT markets Visudyne Therapy and its primary compounds in development are Verteporfin, and QLT 0074. Pharmaceutical company focused on developing reformulated versions of existing drugs. Pharmaceutical company focused on four business areas: fertility control and hormone therapy, diagnostics and radiopharmaceuticals, dermatology as well as therapeutics for disabling diseases, such as multiple sclerosis, leukemia and solid tumors. Biotechnology company focused on developing technology for monoclonal antibodies, antibody-drug conjugates, single chainimmunotoxins, and antibody-directed enzyme prodrug therapy. Seattle Genetics is developing monoclonal antibody based therapeutics for cancer. Develops diagnostic products including Cardiac STATus tests for myocardial infarction and prevacid. Clofibrate and Clorazepate - Ceftin and Coptin and Capoten - Ditropan and Diazepam - Decadron and Percodan - Demerol and Demulen and Dicumarol - Elavil and Aldoril - Lasix and Losec - Mogadon and Modulon - Nardil and Norinyl - Nilstat and Nitrostat - Orinase and Ornade and Ornex - Serax and Eurax - Sinequan and Surgam - Zantca and Xanax - Dicetel and Diclectin Source: Davis, N.M., et al. 1992 ; . Look-alike and sound-alike drug names. Hospital Pharmacy. 27, 95-110. Duration of Therapy The duration of therapy can either be indicated by the total quantity of drug to be dispensed e.g., 30 tablets ; or by a period of time i.e., days, weeks or months ; . For example: Amoxil 250 mg Sig.: One TID x 7 days for bronchitis or Amoxil 250 mg Sig.: One TID for bronchitis Mitte: 21.

Programmed to play musical sounds of varying pitch and intensity according to the depth of the interruption. Little be little, they began to understand that they had something to do with the sounds they could hear. When they kept still, silence prevailed. When they moved, they heard sounds. Some of them realised that they had power to produce sounds, to create and to control something. The wonder and joy of this realisation, filled them with a radiance, and peace. There were some very interesting and rewarding sessions, when a parent and an autistic child communicated with the Soundbeam. With improvised movement, they improvised music, which spoke to them and thus they were able to speak to each other non-verbally. It was a very moving experience for all. Again everyone was adamant: Ssame Autisme had to acquire a Soundbeam. Unfortunately, after the Musical Wheel and other expenses, the budget couldn't rise to the occasion, so Soundbeam remains a dream. But maybe one day. Two months ago, the mother of a 28 year old autistic lady came in and closed the door. She spoke of her terrible anguish : of how she drives off alone in the car and screams and cries, when things become too much for her. She said that twice she had slapped her daughter, and that the look of shock and pain on her daughter's face would live with her always. She asked me to help and zyloprim.

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By total industry patient-days, one would implicitly be assuming that the various drugs are perfectly substitutable. To circumvent this problem, we employ the economic theory of price indexes and calculate the industry price using the Fisher-Ideal price index. I4 In terms of quality, to the extent that product-quality characteristics affect the size of the potential market, they should be included in an overall industry demand equation. We would expect that the size of the potential patient market would depend on the specific indications for which the FDA has granted approval. We shall concentrate on one particular indication, GERD, which represented an especially large potential new market, and for which the H, antagonists first received FDA approval relatively late in the sample. Specifically, when the FDA granted approval to Glaxo's Zantxc for GERD, Zantac detailers were permitted to provide specific information to physicians concerning the treatment of GERD. This was significant, for instead of being confined to detailing to gastroenterologists who saw ulcer patients, now Zantac detailers also made calls on general practitioners who commonly saw patients having GERD symptoms. This undoubtedly expanded the potential market. Such reasoning suggests that a dummy variable, say, GERD taking the value of 1 following FDA approval ; , be employed in the overall industry demand equation. However, it is worth noting that information concerning the efficacy of drugs for different indications typically diffuses prior to formal FDA approval. The medical community is often aware of results of clinical trials prior to the FDA's reviewing the clinical-trial data and coming to a final decision concerning approval for a new indication. As a result, a great deal of prescribing is done off-label prior to the FDA's granting approval. Thus, it is not clear how reliable the GERD dummy variable will be in capturing major changes in the size of the potential patient base. The third set of factors affecting industry demand involves marketing efforts. Earlier we noted that, in this industry, the two principal forms of marketing efforts are minutes of detailing and either pages or deflated dollars of medical journal advertising. There are several important issues concerning the measurement of marketing efforts. First, since drug marketing is largely a matter of providing information about the existence and usefulness of the product, we expect its impact to be long-lived; once a physician has been informed, it is hard to see how such information might be destroyed. Indeed, precisely because of this durability, firms typically expend a particularly large amount of marketing effort in the early stages of a new product's life. Hence the impact of marketing on sales is likely better measured by the cumulative stock of marketing efforts since product launch, rather than simply by the flow of cur14. Specifically, the Fisher-Ideal price index is the geometric mean of the Laspeyres and Paasche price indexes, where each of them is computed using updated weights. New products are incorporated as soon as is feasible i.e., in the second period of their existence, so that their first difference is calculated ; . For further details concerning the Fisher-Ideal price index, see Diewert 1981, 1992 and proventil.

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People with diabetes don't need to go out and purchase special foods to maintain a diabetic diet, they can eat the same foods as the whole family. Group ; . This is practicing and dispensing medication without a license. Liability also exists for potential misdiagnosis, allergic reactions, harmful side effects, and drug interactions. Having said that, the good news is most doctors will prescribe appropriate medications for their patients when Unfortunately, when it comes to these supplies, most of they travel. Really. Just ask for the common medications us stock medical kits like a bad salad, too heavy on the antibiotics or painkillers ; that may be helpful in a remote, dressings and too light every where else. While wound care wilderness setting. Ask for specific instructions for use supplies are vital especially knuckle Band-Aids ; , it is just as including dosing, and potential side effects, or common important to focus on the minor ailment stuff for those drug interactions. If your doc doesn't want to do it, find pesky little afflictions that'll drive you nuts and possibly one who will. We're out there. others ; , like a toothache or an unrelenting, nighttime Otherwise, and even better, is to try to get individuals to cough. You don't need an entire pharmacy, but you do need carry their own antibiotics or other prescription medication more than a couple of aspirin. See list. ; from their doctor with specific instructions for use in cerWhile there are no hard and fast rules, here are a few tain situations, especially if they suggestions. First, remember that if the bowels are happy, you're happy. ". a medical kit can make are prone to certain problems. For example, a woman prone to Diarrhea is a horrible, frustrating or break an entire trip, or bladder infections should try to thing on a river trip. Bring an antikeep it from launching get the appropriate antibiotic supdiarrheal such as Imodium AD. see shouldn't be AmmoCanDoc, A River Runs altogether. ply for her trip. Itof "the medic" the responsibility Through Me, the Waiting List, Feb. Like personal flotation on the trip to provide a cornu1999, pg. 24, May 1999, pg. 26 ; For floatin' and bloatin, ' consider devices, they are copia of medications. It can be a gets Ducolax, which is good for constipamandatory for boaters never-ending battle, and itit's really expensive. For what tion. For the stubborn variety, bring on most permitted worth, if I had one oral antibiotic the suppository form of Ducolax as well, so you can sneak up on it from whitewater rivers." to bring it wound be Keflex cephalexin ; which is good for behind. Pepto-Bismol, or Mylanta skin or wound infections, as well as upper respiratory infeccan help an upset stomach, and consider Zantac for hearttions bronchitis or sinusitis ; . My prescription painkiller burn after too much spaghetti or one too many brewskis. would be Vicodin. It is moderately potent and tolerated While cold and cough preparations are a dime a dozen, fairly well. Robitussin DM is probably the best bang for the buck for a A few quick final pearls: relatively primitive but invalunagging cough and Sudafed for congestion alone. For the able medical tools include a reliable watch, a good tweezers, combo sneezing, sniffling, stuffy nose, coughing, so-youa decent scissors and a SAM splint. A watch with a second can-rest medicine, Dimetapp, Contac, or Tylenol Cold hand or digital readout is good for monitoring vital signs, Sinus is probably reasonable. Plain Benadryl is a good antii.e. pulse and respirations, which can make a sick or histamine for itching or allergic reactions. Vitamin I injured person think you're "doing something" even if ibuprofen ; is good for inflamed aching, sore joints, and you're not, and can keep you from being late for dinner on Tylenol for fever or pain, and for those who can't stomach enchilada night ; . Invest in a good tweezers forceps ; , one ibuprofen. Oragel or Eugenol can help a toothache. A good with a fairly pointed end that closes really well. They're skin moisturizer Curel, petroleum jelly ; is mandatory for great for everything from teeny, weenie splinters to eyeglass any attempt at healthy skin. Superglue is excellent for crackscrews. A good small scissors and EMT shears for cutting ing skin see AmmoCanDoc, Summer 2000, the Waiting tape, bandages, moleskin etc., is worth the money. SAM List, pg.28 ; , and you can never have too much sunscreen. splints are the greatest things since sliced bread for splinting As for prescription medications, anyone whose ever done orthopedic injuries. a long wilderness trip knows being able to render antibiotics Lastly, where do store all this stuff? For river trips it's usuor prescription pain killers to a suffering comrade can seem ally easy because space shouldn't be an issue except unsuplike nothing short of bestowing manna from heaven. ported kayak trips ; . A 20 mm. ammo can is great for the However: It is illegal for someone who is not licensed to major medical, and smaller ammo cans for the minor first dispense prescription medications to friends or others i.e. a aid. Make sure they don't leak! Test them empty in the group leader cannot share or give them to others in the bathtub ; . They should ideally be painted continued on next page and prednisolone.

Procedure View current medications list. Expected Result All current medications display: Actos 30 mg once daily Aleve Glucosamine chondroitin Lipitor 20 mg a day Lisinopril 10 mg a day Saw palmetto Synthroid 0.112 mg a day Tums 750 mg several times a day Zantac 150 mg a day Applicant demonstrates this function. It is acceptable to either show a look-up using physician preferences or creating a new saved list. Notes from at least two previous visits as entered from appendix information ; are available.

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Parallel imports What the Medicines Act says: The Minister of Health can prescribe conditions for the supply of more affordable medicines in certain circumstances to protect the health of the public. The law also allows the Minister of Health to import the same medicines made by the same company or someone they had licensed if it is sold at a cheaper price in another country. The Zantac Example Glaxo sells Zantac 10 x 300mg ; at a very low price in India and at a very high price in the USA or Indonesia. Glaxo Wellcome prices in rupees April 1998 ; India Indonesia Britain USA Rs17.39 Rs658.36 Rs603.24 Rs1200.38 and prednisone and Buy cheap zantac.
I have been naucious for over 2 years and i finally getting relief. Coordinator: Dr. G. P. S. Raghava 1. Major achievements made during 2004-05 5 lines ; Protein Structure Prediction: Prediction of structure of proteins from their amino acid sequence is our main area of research. Under this project, we developed number of programs and web servers for predicting secondary and tertiary structure of proteins. We participate in International third fourth community wide experiment on the 'Critical Assessment of Techniques for Protein Structure Prediction CASP ; . Where we predicted protein structure secondary tertiary ; of all targets with reasonable accuracy using methods developed at our centre. We were considered in category of successful predictors in this community wide experiment. We also participated in fully automatic servers competition called CAFASP2 Critical Assessment of Fully Automatic Structure Prediction ; . Our group is the only group in India who participated in these advance levels of experiments CASP4, CASP5, CAFASP2, CAFASP3 & EVA ; . From Asia continent there were only three web servers one from Japan and two from our group India ; who participated in CAFASP2. Gene Prediction and Genome Annotation: Assign coding genes in genome is one of the major challenges in genomics. We developed web server called FTG for locating probable gene in a nucleotide sequence using fast fourier transform. Under this project our aim is to improve the accuracy of gene prediction particularly at level of exon and intron. We also developed web server called GWBLAST and GWFASTA that allow to perform BLAST and FASTA against all sequenced genome finished or unfinished as well as against their proteins. This will help in annotating and analyzing the coming up genomes. Prediction of T Cell epitopes: Identification of peptides that elicit a T cell response plays a vital role in vaccine design. It is well established that MHC peptide binding is prerequisite for T-cell recognition TCR ; but not all MHC peptide binding site do not recognize the T cells. We are working to develop new methods for prediction of T-cell epitopes in antigen sequences. Recently, a server for predicting MHC binding sites has been developed. The prediction method used in this server is based on matrix optimization techniques MOT ; . A server called Propred has been developed to predict MHC binding sites for 51 class II alleles and also allow to predict promiscuous MHC binders. Biocomputing: This centre is actively involved in research in area of Biocomputing, since, 1990. Here, main emphasis is to solve the general biological problems and to develop computer software. We have developed number of software particularly in immunology for Ab Ag Concentration; Ab Ag affinity etc. ; , Molecular Biology Synthetic gene design; Redesign of natural genes; Computation of DNA Protein size; Optimization of Gel-electrophoresis etc. ; and Cell Biology Hemolytic potency of drugs and ventolin.

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The Medicaid Pharmacy Q&A has been developed to provide guidance and clarification on pharmacy issues. Questions may be submitted to: Medicaid Program Management, Fax 334 ; 353-7014 Responses will be published in the quarterly Medicaid Pharmacy Newsletter. Are original prescriptions and signatures required for all drugs? Medicaid requires original, signed prescriptions for Schedule II drugs and Brand Medically Necessary drugs. Schedule III, IV, and V drugs may be called in, as allowed by state pharmacy regulations. Can a call-in prescription be accepted for a MAC drug when brand necessary certification is required? No. The MAC price may only be waived when a pharmacy has a prescription with "Brand Medically Necessary" written in the prescribing physician's own handwriting. Therefore, a written prescription is necessary. For example, because Zantac is a MAC drug and requires brand medically necessary certification on the prescription, a telephone prescription would not be acceptable in order to receive brand reimbursement. Thanks again to all who contributed to this forum it has been very helpful to guiding me as to what i should do as i really opposed to taking drugs but i guess there is a time when we are thankfull to find one that works.

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Next, we set Zantac's detailing level equal to Tagamet's. Recall that Zantac detailed much more heavily than Tagamet, so in effect we are decreasing Zantac's detailing. The result is that Zantac's sales are much lower by the end of the period, and the sales of Tagamet, Axid, and Pepcid are all higher. This is due to the large estimates about 1.0 ; of the advertising elasticities of demand in the equilibrium share model. Table 5 shows the impact on Zantac's cumulative gross profits, ignoring production costs which are small ; , but accounting for detailing costs, which are estimated annually from aggregate pharmaceutical industry data.13 Observe that although Zantac's detailing expenditures drop, its sales drop by so much that its cumulative profits fall by almost 0 million. Lastly, we evaluate the effect of past sales on the rate of brand diffusion. This effect is captured by the coefficient d1 in the diffusion equations; note from column 1 ; of Table 4 that the estimated value for d1 is 0.0180. We. Introduction Fish farming in Finland is an important source of livelihood for distant areas in the southwestern archipelago or in freshwater lake area. Unfortunately, the same areas are used for recreational purposes, e.g., for summerhouses, thus creating conflicts between fish farmers and the other users. The species farmed for direct human consumption is almost completely the rainbow trout. For stocking purposes there is a remarkable diversification of the species. The rainbow trout is now frequently on the Finnish food table. About 2.7 kg per inhabitant was consumed in 1997 in the same year the total consumption of fish per inhabitant was about 30 kg and of this about 15 kg was the share of imported products ; . Fish farming in Finland was developing rather fast until the beginning of 1990s. In 1991 there was a turning point: since then the production has been decreasing almost every year see Figure A8.1 ; . The reason for the decrease is the concurrence of imported fresh fish products, mainly salmon and rainbow trout from Norway. The price development is clearly indicated in the corrected annual real value of the production shown in Figure 1. In 1998 the import from Norway reached the level of 6 million kg. Of this amount, about 1.3 milllion kg were fresh trout and about 4.6 million kg were fresh salmon. The proportion of the import on the Finnish fresh salmon and trout market has thus grown from zero to almost 40 % in less than 10 years and buy carafate. Anti-virals HIV medicines grew across all regions and totalled 1.5 billion in sales, up 13 per cent. Sales of Trizivir, GlaxoSmithKline's new triple combination therapy, grew 95 per cent to 315 million. Valtrex, for herpes, continued to benefit from its convenient once-daily dosing for suppressive therapy and achieved strong sales growth of 26 per cent worldwide and 35 per cent in the USA. In October 2002, GlaxoSmithKline filed an sNDA for Valtrex seeking the first-ever indication to reduce the risk of transmission of genital herpes. In December 2002, GlaxoSmithKline filed an NDA for `908', a protease inhibitor, for the treatment of HIV. The decline in Zovirax sales reflected transfers to the newer Valtrex and generic competition. Anti-bacterials Anti-bacterial sales declined 12 per cent worldwide and 22 per cent in the USA. Augmentin's US sales were down 20 per cent in the year as a result of generic competition that began in the third quarter. Four generic versions of Augmentin have been introduced in the USA following a decision by the US District Court for Eastern Virginia that held invalid GlaxoSmithKline's patents on Augmentin expiring in 2002, 2017 and 2018. A hearing on GlaxoSmithKline's appeal of the court's decisions has been scheduled for 5th March 2003. US sales of Ceftin declined 80 per cent, due to generic competition which began during the first quarter, 2002. In the USA, GlaxoSmithKline's two new antibiotics, Augmentin ES for children, and Augmentin XR for adults, are performing well. The ES formulation, launched in the fourth quarter of 2001, now represents 49 per cent of all branded and generic Augmentin paediatric prescriptions. Based on recent weekly data, the XR formulation, launched in October, now represents 14 per cent of all branded and generic Augmentin adult prescriptions. Metabolic and gastro-intestinal Worldwide sales for the metabolic and gastro-intestinal category were 1.4 billion, up one per cent. The Avandia franchise Avandia and Avandamet ; grew 19 per cent for the year with US sales up 15 per cent to 688 million. Avandamet, a combination of Avandia and metformin HCI, expanded the Avandia metabolic franchise with its US launch in the fourth quarter. Avandamet for the treatment of type 2 diabetes is the first medicine that targets insulin resistance and decreases glucose production in one convenient pill. Since its approval by the FDA in May 1999, Avandia has been used by over four million patients worldwide. Zantac sales were 382 million down 21 per cent ; with declines in most markets. Vaccines Sales of vaccines grew 16 per cent to over 1 billion, supported by the Hepatitis franchise, up 12 per cent to 483 million, with total sales in Europe growing 17 per cent. US sales grew 16 per cent from the launch of Twinrix and continued growth in Havrix, driven by new state mandates requiring Hepatitis A vaccination of school age children. Infanrix GlaxoSmithKline's DTPa range of combination vaccines ; grew eight per cent to 254 million. Priorix and Tritanrix grew 29 per cent and 54 per cent respectively. In the USA, GlaxoSmithKline's new Pediarix vaccine was launched in January 2003. Pediarix adds protection against hepatitis B and poliomyelitis to the Infanrix combination, and results in up to six fewer injections for infants.
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